GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| THCA | trans | rs965513 | 1 | rs7864322 | chr9:100548934 | EML5 | chr14:89081205-89259157:- | 0.3 | 6.86 | 2.13E-11 | Thyroid cancer (Papillary, radiation-related);Thyroid cancer |
| THCA | trans | rs965513 | 1 | rs7864322 | chr9:100548934 | EPDR1 | chr7:37960163-37991539:+ | 0.32 | 7.11 | 4.27E-12 | Thyroid cancer (Papillary, radiation-related);Thyroid cancer |
| THCA | trans | rs965513 | 1 | rs7864322 | chr9:100548934 | GGT5 | chr22:24615623-24641110:- | 0.26 | 5.95 | 5.33E-9 | Thyroid cancer (Papillary, radiation-related);Thyroid cancer |
| THCA | trans | rs965513 | 1 | rs7864322 | chr9:100548934 | LRRC42 | chr1:54412037-54433839:+ | -0.23 | -6.06 | 2.78E-9 | Thyroid cancer (Papillary, radiation-related);Thyroid cancer |
| THCA | trans | rs965513 | 1 | rs7864322 | chr9:100548934 | NKX6-1 | chr4:85414436-85419387:- | 0.5 | 8.81 | 2.25E-17 | Thyroid cancer (Papillary, radiation-related);Thyroid cancer |
| THCA | trans | rs965513 | 1 | rs7864322 | chr9:100548934 | PLCE1 | chr10:95753746-96088146:+ | 0.27 | 6.15 | 1.64E-9 | Thyroid cancer (Papillary, radiation-related);Thyroid cancer |
| THCA | trans | rs7903456 | 1 | rs7903456 | chr10:88919319 | FAM35B | chr10:46897641-46939143:+ | 0.37 | 7.23 | 1.87E-12 | Renal underexcretion gout;Gout |
| THCA | trans | rs804280 | 1 | rs804280 | chr8:11612698 | SGK223 | chr8:8175259-8239257:- | -0.36 | -6.59 | 1.18E-10 | Myopia (pathological) |
| THCA | trans | rs853679 | 1 | rs853676 | chr6:28299687 | BTN3A2 | chr6:26365398-26378546:+ | -0.46 | -8.87 | 1.52E-17 | Depression |
| THCA | trans | rs853679 | 1 | rs853678 | chr6:28297313 | BTN3A2 | chr6:26365398-26378546:+ | -0.44 | -8.66 | 7.5E-17 | Depression |
| THCA | trans | rs853679 | 1 | rs853679 | chr6:28296863 | BTN3A2 | chr6:26365398-26378546:+ | -0.44 | -8.66 | 7.5E-17 | Depression |
| THCA | trans | rs853679 | 1 | rs853685 | chr6:28288785 | BTN3A2 | chr6:26365398-26378546:+ | -0.45 | -8.82 | 2.07E-17 | Depression |
| THCA | trans | rs853679 | 1 | rs853694 | chr6:28279100 | BTN3A2 | chr6:26365398-26378546:+ | -0.46 | -9.11 | 2.31E-18 | Depression |
| THCA | trans | rs877636 | 1 | rs877636 | chr12:56480583 | RPS26P11 | chrX:71264259-71264809:+ | -0.49 | -8.83 | 1.98E-17 | Cognitive function |
| THCA | trans | rs965513 | 1 | rs925488 | chr9:100546391 | ABCC11 | chr16:48200822-48281479:- | 0.3 | 6.11 | 2.02E-9 | Thyroid cancer (Papillary, radiation-related);Thyroid cancer |